The protected mode also appears to break communication to Adobe Reader via an Adobe plug-in. Printing stopped when I installed Adobe Reader X.Programmatically disabling the protection mode by modifying the Privileged\bProtectedMode Registry key seems to circumvent the problem.
Plug-ins that worked in Reader 9 or lower may need to be rewritten for Reader X when in Protected Mode if they use any functions that need to interact with the OS. Reader Protected Mode shields the OS from security risks by forcing plug-ins to go through a broker process before executing certain functions.
This key fixed the problem
HKEY_CURRENT_USER\software\adobe\acrobat reader\10.0\privileged bProtectedMode REG_DWORD 0×0
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